A study in mice with fragile X syndrome found wiring in the part of the brain that responds to touch is formed late.
The findings may help explain why people with the condition are hypersensitive to physical contact, the researchers wrote in Neuron.
It also points to key stages when treatment could be most effective.
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The study also found these changes in the brain's connections occur much earlier than previously thought, midway through a baby's development in the womb.
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